|
KMID : 1007520000090040249
|
|
Food Science and Biotechnology
2000 Volume.9 No. 4 p.249 ~ p.252
|
|
|
Effects of Soy Isoflavone - supplemented Diets on Benzo(a)pyrene - induced Lung and Forestomach Tumorigenesis in Mice
|
|
Kwon, Tai Wan
Kim, Jong Sang/Kwon, Chong Suk
|
|
|
Abstract
|
|
|
|
As soy isoflavones have been reported to prevent some hormone-independent cancers and upregulate tissue detoxifying enzymes, these components have been tested for their potential to inhibit chemical carcinogenesis. Mice were randomly allocated into four experimental groups (20 mice per group) including a positive control, which was intubated with benzo(a)pyrene (BP) with feeding basal diet, or diet containing 0.2, 1 and 2 g/㎏ semi-purified (SP) isoflavones. Mice fed diet containing 0.2 g/㎏ SP isoflavones showed significantly higher total body weight gain and daily diet intake than the control group. Tumor incidences in the forestomach were the lowest in 0.2 g/㎏ SP isoflavone group (88%) while those of the control, 1 and 2 g/㎏ isoflavone groups were higher than 94%. Proportion of mice bearing more than 10 tumors was 33% in 0.2 g/㎏ SP isoflavone group versus 67% in control group, indicating a strong association of isoflavone intake level with the prevention of chemical tumorigenesis. Lung tumor development was most effectively inhibited by feeding 1 g/㎏ SP isoflavone-supplemented diet, while the cancer preventive effect decreased at higher level of SP isoflavones (2 g/㎏ diet). These results suggest that isoflavones have differential preventive effect on the BP-induced tumor development in forestomach and lung.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|